The strangeness S=−3 and −4 baryon-baryon interactions are investigated in the relativistic chiral effective field theory at leading order. First, the potentials are derived from the S=−1 sector assuming that the corresponding low-energy constants are related to each other via SU(3) flavor symmetry. The comparison with the state-of-the-art lattice QCD simulations, show, however, that SU(3) flavor symmetry breaking effects can not be neglected. In order to take into account these effects, we redetermine two sets of low-energy constants by fitting to the lattice QCD data in the ΞΣ
Nearby in the stack
and
ΞΞ
channels respectively. The fitting results demonstrate that the lattice QCD
S
-waves phase shifts for both channels can be described rather well. Without any additional free low-energy constants, the predicted phase shifts for the
3D1
channel and the mixing angle
ε1
are also in qualitative agreement with the lattice QCD data for the
S=−3
channel, while the results for the
S=−4
channel remain to be checked by future lattice QCD simulations. With the so-obtained low-energy constants, the
S
-wave scattering lengths and effective ranges are calculated for these two channels at the physical point. Finally, in combination with the
S=0
and
−2
results obtained in our previous works, we study the evolution of the irreducible representation
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in the baryon-baryon interactions as a function of increasing strangeness. It is shown that the attraction decreases dramatically as strangeness increases from
S=0
to
S=−2
, but then remains relatively stable until
S=−4
. The results indicate that the existence of bound states in the